Goal. Investigate the possibility to use 1,8-naphthalic anhydride metabolism inductor to control acetolactate synthase (ALS) inhibitor-resistant biotype of common graminicides of aryloxyphenoxypropionic acid class in rice. Methodology. The interaction of 1,8-naphthalic anhydride and fenoxaprop-p-ethyl on variety Vikont rice plants was studied under laboratory aseptic conditions. The data were statistically processed. Results. In Ukraine we have identified the biotype of resistant to herbicide - ALS inhibitors Echinochloa crus-galli, which is cross-resistant to widely used herbicides - ALS inhibitors of the following chemical classes: imidazolinones (imazamox, imazapyr), sulfonylurea (nicosulfuron), triazolopyrimidines (penoxsulam). The possibilities of chemical control of weeds in rice, corn, sunflower, etc. crops are significantly limited. Multi-resistance of this weed biotype to herbicides - inhibitors of photosynthesis, mitotic cycle, 5-enolpyruvylshikimate-3-phosphate synthase, acetyl-CoA-carboxylase, protein synthesis - has not been detected. Therefore, the use of graminicides of aryloxyphenoxypropionate class is promising for the control of this ALS-resistant biotype of Echinochloa crus-galli. To increase the selectivity of fenoxaprop-P-ethyl application to rice plants, we propose to treat the seeds of the crop with the inductor of xenobiotics metabolism in plants - 1.8-naphthalic anhydride before sowing. When using 1.8-naphthalic anhydride in concentrations of 10^-5 M, phytotoxicity of fenoxaprop-P-ethyl in concentrations of 10^-6 and 10^-5 M to rice plants is effectively reduced. Conclusions. The use of 1.8-naphthalic anhydride is promising for increasing the selectivity of fenoxaprop-P-ethyl for rice plants and allows the development of technologies using graminicides of aryloxyphenoxypropionate class to control ALS-resistant biotype of Echinochloa crus-galli in crops. Also, it is necessary to pay attention to the problem of ALS-resistant weed biotype proliferation control in agrophytocenoses in regions of Ukraine.